Thanks for your help Stewie 
I am able to open depositfiles with a proxy but not able to download or upload anything.
Is downloading/uploading not possible using proxy ? Any Idea.
Is there anyway I can download/upload from depositfiles ?
You can download via a proxy but if its a popular one, the ip address can max-out quickly, meaning the daily limit is soon reached. You have to search around to find a stable, less commonly used proxy and try at various times of the day. It's not ideal, but probably the only way.
I use FoxyProxy basic for Firefox, which allows you to quickly add and select these random proxy addresses.